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Mannitol

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. 


Application

1. In medicine field, mannitol injection act as a high-permeability antihypertensive drug, it has the effect of fast buck.
2. Applied in the food field, Mannitol is non-hygroscopic, meaning it doesn't attract and hold water. However, it is water-soluble. That's why candy makers use mannitol to make hard candy coatings on chocolate, sugar-free products, and chewable disintegrating tablets. It's also a helpful anti-caking substance. Mannitol is also popular in baking, as its high melting point (165 degrees Fahrenheit) prevents unsightly browning on baked goods.


Product specification

Test Item

 Standard

 Result

 

Appearance

White crystalline

powder

White crystalline

powder

 

Assay(on dry basis)

             97-102

                     99.61

Water,%

 ≤0.5

0.08

Melting Point,ºC

 165-170

 

167.5

Nickel,ppm

 ≤1

<1

Heavy Meltal,ppm

 ≤5

<5

 

Specific Rotation

 +23-+25

+24.3

Electrical conductivity,Hs/cm

             ≤20

 3.66

Reducing Sugars,%

           ≤0.1

           <0.1

Endotoxins,EU/g

          ≤2.5

<2.5

The total no. of aerobe,cfu/g

          ≤100

<10

Fungi cfu/g

      ≤100

<10

Escherichia coli

25g Negative

      Negative

Salmonella

                25g Negative

         Negative

Sorbitol,%

  ≤2.0

              <2

Isomalt,%

≤2.0

              <2

Malt,%

≤2.0

              <2

Conclusion: The above product conforms to the standard.